Flint - a simulator for biological and physiological models

Table of Contents


Flint is a simulator for biological and physiological models written in CellML, PHML, and/or SBML.

  • It can solve ordinary differential equations (ODE) numerically, and more.
  • It runs on Windows, macOS, Linux, etc.
  • It provides graphical user interface on top of command-line interface.
  • It is open source under the MIT license.


You can read NEWS about Flint 2.1 released at 2018-10-15.

Flint 2.1.1 has been available for macOS at 2019-02-01, which is just for a quick fix of a crash reproduced only with Flint 2.1 installed by the macOS package.

binary distribution

  • Windows installer for Windows 7 or later
  • Mac installer package for OS X Mavericks (10.9) or later:
    • Flint-2.1.1-mac.dmg (sha1sum: 8892329648cd95a9c747e20d89b014074eeba0e0)
    • note that you may have to change Gatekeeper options if you see an error message like "... is damaged and can't be opened. You should move it to the Trash." at opening the package. If you use macOS Sierra (10.12) or higher, follow the alternative instruction to bypass Gatekeeper.
  • RPM packages

source distribution



Flint's source repository is in GitHub. Patches and/or suggestions are welcome.


To cite Flint in a scientific article:

  • Y. Asai et al., "Multilevel Modeling of Physiological Systems and Simulation Platform: PhysioDesigner, Flint and Flint K3 Service," 2012 IEEE/IPSJ 12th International Symposium on Applications and the Internet, Izmir, 2012, pp. 215-219. doi: 10.1109/SAINT.2012.40



Send email to tabe at fixedpoint dot jp with any questions.